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De novo sequencing
De novo sequencing is an exciting application of our proteases. Krakatoa users performing de novo sequencing of antibodies have reported saving significant time and money by reducing the number of proteases required to achieve sufficient breadth and depth of coverage and get confident results.
See two examples below of using our Krakatoa protease in this application.
1. Example chromatogram showing Trypsin and Krakatoa digest of monoclonal antibodies.
2. Example coverage map showing contribution of Krakatoa, Trypsin, and Asp-N to antibody sequence.
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